Thus, the current study analyzed the genotypic and allelic frequency distribution of eight genetic variants in oxidative-stress related proteins (rs4880-SOD2, rs1001179-CAT, rs1050450-GPX1, rs1695-GSTP1, rs1138272-GSTP1, rs1799983-NOS3, rs6721961-NFE2L2, and rs660339-UCP2) in clinically confirmed migraine subjects and a headache-free control group with SEC origin, in order to investigate their association with migraine susceptibility and diverse clinical phenotypes. This evidence concerns the gene UCP2 and Headache.