TARDBP and proteostasis deficiencies: A related puzzle is the comparative rarity with which proteinopathies such as TDP-43 initially strike the right compared with the left temporal lobe (3, 11): while this could in part reflect ascertainment bias (right-sided presentations are more likely to be overlooked or misattributed to a psychiatric process than language presentations), it may be telling us something of fundamental importance about the relative susceptibility of neural circuitry in the left and right temporal lobes to neurodegeneration.