LDHD and central nervous system cancer: Furthermore, the expressions of HAGH, LDHB, LDHD, SLC16A7, SLC25A12, and TP53 were upregulated, and the expressions of EMB, LDHA, SLC16A3, and SLC16A8 were downregulated in isocitrate dehydrogenase (IDH) wild-type glioma compared with mutant glioma (Figure 1B).