REN and Hyperglycemia: Hyperglycemia levels not only enhance oxidative stress and hemodynamic factors such as activation of the renin-angiotensin-aldosterone system and impaired self-regulation due to systemic hypertension, but also increase the load of glucose delivered to the proximal tubules, triggering maladaptive hypertrophy (39) and hyperplasia of cortical tubules, and upregulation of glucose transport (40), and activation of globular feedback, leading to hyperfiltration of glomeruli and tubular fibrosis.