However, there were no significant associations of serum FXIII-A concentration with age, duration of diabetes, diabetic retinopathy, body mass index (BMI), HbA1c, serum total cholesterol and triglycerides level, amounts of proteinuria, serum albumin level and percentage of hypertension and renin-angiotensinaldosterone system (RAAS) inhibitor use (Table 1). This evidence concerns the gene REN and diabetic retinopathy.