The serum samples showing the strongest inhibitory effects on the production of the chemokines were from two AOSD patients (P1 and P2) who had high-titer anti-IFN-γ autoAbs and OIs (IP-10: 16.69 and 3.13 pg/ml; MCP-1: 24.24 and 15.63 pg/ml, respectively). This evidence concerns the gene IFNG and adult-onset Still disease.