Accordingly, neutralizing anti-IFN-γ autoAbs are recognized as a cause of adult-onset immunodeficiency (AOID) and associated with increased risks of opportunistic infections (OIs) such as disseminated non-tuberculous mycobacteria (NTM), non-typhoid Salmonella, Cryptococcus, and varicella-zoster virus (VZV), particularly in Asian populations (3–9). This evidence concerns the gene IFNG and Opportunistic infection.