Significantly higher titers of anti-IFN-γ autoAbs were also observed in AOSD patients [median 20.97 U/ml, interquartile range (IQR) 7.01–27.56 U/ml) than HC (0.44 U/ml, IQR: 0.44–9.87 U/ml, p < 0.001, Figure 1B). Here, IFNG is linked to adult-onset Still disease.