The level of IL-8 concentration in the aqueous humor of patients with OAG secondary to PSS (145.10 [0.00-337.20] pg/ml) was significantly higher than that in the PSS group (12.20 [4.70-58.50] pg/ml); the difference was statistically significant (p = 0.0229). This evidence concerns the gene CXCL8 and peeling skin syndrome.