Based on these results, 4c was further evaluated in 3 x Tg mice and APP/PS1 mice, which present typical Tau pathology and amyloid-dependent pathology, respectively (Billings et al., 2005; Tahara et al., 2006; Yuan et al., 2011; Huber et al., 2018; Fang et al., 2019). The gene discussed is MAPT; the disease is amyloidosis.