MAPT and Alzheimer disease: In addition, treatment of 3 x Tg mice with 4c significantly reduced the hyperphosphorylation of Tau at Ser202/Thr205, Thr231, and Thr181, the common sites of hyperphosphorylation in AD patients and AD mice (Hanger et al., 2007; Spillantini and Goedert, 2013; Fang et al., 2019) (Figure 5).