PSEN1 and Alzheimer disease: Single nucleotide polymorphisms (SNPs) or mutations in more than 100 genes have been linked to the increased risk of AD, including App, Psen1, Psen2, Apoe, Trem2, Pon1, Aph1b, Adam10, Clu, Abca7, Slc24a4, and Tomm40 (Cacace et al., 2016; Nie et al., 2017; Chiba-Falek et al., 2018; Kim, 2018; De Roeck et al., 2019; Bertram and Tanzi, 2020).