The effects of 4c and Evo on cognitive decline were assessed in APP/PS1 mice that express the APPswe and PS1ΔE9 mutant genes and develop a more typical amyloid-dependent pathology than 3 × Tg AD mice (Billings et al., 2005; Tahara et al., 2006; Yuan et al., 2011; Huber et al., 2018; Fang et al., 2019). Here, PSEN1 is linked to Alzheimer disease.