Single nucleotide polymorphisms (SNPs) or mutations in more than 100 genes have been linked to the increased risk of AD, including App, Psen1, Psen2, Apoe, Trem2, Pon1, Aph1b, Adam10, Clu, Abca7, Slc24a4, and Tomm40 (Cacace et al., 2016; Nie et al., 2017; Chiba-Falek et al., 2018; Kim, 2018; De Roeck et al., 2019; Bertram and Tanzi, 2020). This evidence concerns the gene APP and Alzheimer disease.