We evaluated the effects of compound 4c on cognitive decline and Tau-dependent pathology in 3 x Tg mice, which develop more typical Tau phosphorylation than APP/PS1 AD mice (Billings et al., 2005; Yuan et al., 2011; Huber et al., 2018; Fang et al., 2019). The gene discussed is PSEN1; the disease is Alzheimer disease.