Silencing of CMTM6 in head and neck squamous cell carcinoma (HNSCC) reduces β-catenin expression, inhibits stem cell properties, suppresses epithelial-to-mesenchymal transition (EMT) and cell proliferation, and promotes CD8+ and CD4+ t-cell infiltration (Chen et al., 2020). This evidence concerns the gene CD4 and head and neck squamous cell carcinoma.