CMTM6 and hepatocellular carcinoma: For example, CMTM6 sensitizes HCC cells to cisplatin and doxorubicin (Huang et al., 2022), and knockdown of CMTM6 in OSCC cells restores cisplatin-mediated cell death, and conversely overexpression rescues the drug-resistant phenotype of the cells (Mohapatra et al., 2021).