CMTM6 and hepatocellular carcinoma: However, some studies have also shown that the expression of CMTM6 is positively correlated with vimentin, and interacts with vimentin to promote EMT, which in turn promotes migration, proliferation and invasion, and high expression of CMTM6 predicts poor prognosis in HCC (Huang et al., 2021; Yugawa et al., 2021).