Mostly during the early stages of AD, beta-amyloid (Aβ) protein secreted from neurons misfolds and forms senile plaques in the extracellular space of neuronal cells that leads to the formation of neurofibrillary tangles that is an aggregate of hyperphosphorylated Tau protein (Murphy and LeVine 3rd, 2010). This evidence concerns the gene MAPT and Alzheimer disease.