A similar effect was previously observed in the context of stem cell transplantations, as patients that received DNMT3A mutated stem cells showed increased survival and better engraftment of their stem cells.49 It is unclear how DNMT3A mutations positively affect the survival of thrombocytosis cases, but this seems at the root of an interesting phenomenon that has been observed more frequently in the context of deregulated hematopoiesis. The gene discussed is DNMT3A; the disease is thrombocytosis disease.