TP53 and polycythemia: This effect was not observed in the oldest old (80+) Lifelines participants or in cases with anemia, monocytosis, or erythrocytosis that carried TP53 mutations from the Lifelines population-based cohort, and seems therefore specific for individuals with thrombocytopenia.7,16,23,32 We identified 10 of 11 TP53 mutations in cases with isolated thrombocytopenia.