In combination with CH, cytopenia (as such called clonal cytopenia of undetermined significance [CCUS]) may indicate a bone marrow abnormality and is associated with an increased risk of evolving into a hematological malignancy.10,21 Recently, the association between CH and anemia as well as neutropenia and monocytosis has been studied.7,22,23 In a population-based case–control study, a higher prevalence of CH, particularly with SF3B1 and TP53 mutations, has been observed in older individuals with anemia. The gene discussed is TP53; the disease is anemia (phenotype).