This revealed that the presence of a mutation in TP53 (HR = 5.83, 95% CI, 2.49-13.64; P < 0.001) or in one of the spliceosome-associated genes (HR = 2.69, 95% CI, 1.29-5.63; P = 0.009) significantly increased the risk of death for individuals with thrombocytopenia (Figure 5E; Suppl. The gene discussed is TP53; the disease is Thrombocytopenia.