TNF and Iron deficiency anemia: Iron deficiency per se also has a profound impact on other immune cells, which, in children in the first stage, is associated with Th1-associated cytokines such as IL6, TNFα, and IFN-γ inflammation (96) and, in later stages of more severe cases of iron-deficient anemia, this is associated with the Th2-associated cytokine IL4 (96–98).