3.4. SMW and SMW-BI regulated the insulin receptor substrate 1 (IRS1)/RAC-beta serine/threonine-protein kinase (AKT2)/forkhead box protein O1 (FOXO1)/glucose transporter type 2 (GLUT2) axis in the T2DM mouse liver. This evidence concerns the gene AKT2 and type 2 diabetes mellitus.