For example, hsa_circ_0001666 inhibited epithelial-mesenchymal transition (EMT) and stemness of colorectal cancer (CRC) cells by competitively binding to miR-576-5p and high expression of hsa_circ_0001666 were associated with better clinical prognosis in CRC patients (13); CircZEB1 promoted the expression of PIK3CA by targeting miR-199a-3p to affect the proliferation and apoptosis of hepatocellular carcinoma (HCC) (14). The gene discussed is PIK3CA; the disease is hepatocellular carcinoma.