IL7 and metastatic malignant neoplasm in the lymph nodes: Polymorphism rs6897932 in IL7R has been reported to be positively correlated with histopathological grade and lymph node metastasis in breast cancer (26), but no study has shown that genetic polymorphisms rs1494555, and rs6897932 are associated with an increased risk of irAEs, although these changes may suggest that changes in IL-7 may alter the balance between the membrane-bound (IL-7Rα) and soluble (sIL-7Rα) isoforms of this protein promoting excessive T cell growth and survival.