These included genes consistent with pro-inflammatory immune responses (CD27, CD28, CD3e, CD8a, ICOS, ICOSLG, Pax5, TBX, GATA3, HLA-A, TNFSF14, GPR146), but also immune suppressive influences in the tumor immune microenvironment (CTLA-4, FoxP3, PD-1). This evidence concerns the gene ICOSLG and neoplasm.