CD28 and neoplasm: We also evaluated correlations between CD3+ T cell density and immune gene expression and key genes associated with cytotoxic anti-tumor T cell responses (GZMA, GZMB, PRF1), co-stimulation of T cells (CD27, CD28, ICOS), and genes associated with other immune processes, including Type I IFN response (TNF, TNFSF10), as well as T cell exhaustion (CTLA4), were identified.