CD8A and esophageal squamous cell carcinoma: analyzed the intratumoral and peritumoral tissues of 149 ESCC patients using immunohistochemical analysis, and found that CAFs were negatively and positively correlated with CD8+ tumor-infiltrating lymphocytes (TILs) and forkhead box protein 3 (FoxP3+) TILs in intratumoral tissues, respectively (50).