The NOL1 rs3764909 (AC/CC versus AA: adjusted OR = 1.684, 95% CI = 1.408–2.014, p < 0.001) and NSUN4 rs10252 (adjusted OR = 1.140, 95% CI = 1.001–1.298, p = 0.049) variant alleles were associated with an increased risk of ALL. Here, NOP2 is linked to acute lymphoblastic leukemia.