Five m5C modification core gene SNPs (NOL1 rs3764909 C>A, NSUN3 rs7653521 T>C, NSUN4 rs10252 G>A, NSUN5 rs1880948 G>A, and NSUN6 rs3740102 C>A) were genotyped in 808 pediatric ALL samples and 1,340 age- and gender-matched healthy controls. The gene discussed is NSUN3; the disease is acute lymphoblastic leukemia.