We found that exogenous overexpression of SMOC2 exhibited no significant effect on the expression of RUNX2 by real-time PCR and western blotting analysis; BMP9 increased the expression of RUNX2 in MEFs, which was enhanced when combined with AdSMOC2 infection (Figures 2(a)–2(c)). This evidence concerns the gene RUNX2 and infection.