MPs can deliver tumor cells antigens or other autologous cell‐associated antigens to DCs and induce CD8+ T‐cell‐dependent anti‐tumor responses or immunosuppressive responses in vivo.[8, 9] MPs produced by ultraviolet (UV)‐irradiated tumors combined with methotrexate have been tested in patients with extrahepatic cholangiocarcinoma or malignant pleural effusion and showed good therapeutic effect.[10, 11, 12]. This evidence concerns the gene CD8A and neoplasm.