Related studies have reported that radiotherapy can stimulate the expression of PD‐L1 in tumor cells and a large number of RMPs released by tumor cells also contain this molecule, which may dampen the killing effect of cytotoxic T cells.[36] For this reason, we combined i.v. injection of P5091@RMPs‐R4F with i.p. injection of PD‐1 antibody by shielding PD‐L1/PD‐1 signal axis in peripheral or lymph nodes, thus further promoting the anti‐tumor immunity of RMPs. This evidence concerns the gene CD274 and neoplasm.