USP7 and lung adenocarcinoma: The results showed that USP7 was not only highly expressed in brain metastases of the commonly used murine Lewis tumor model (Figure S1, Supporting Information) but also in human primary lung adenocarcinoma (A07, B09, G01) and brain metastases (Figure 2A, F03, H09, G11), indicating that USP7 is a potential target for the treatment of BRM.