To further improve the ability of RMPs to cross the BBB, we expressed an scavenger receptor‐B1 (SR‐B1)‐targeting peptide on the outer surface of RMPs through genetic engineering, as SR‐B1 receptor was reported to be expressed in BBB endothelial cells, M2Ф/microglial cells, and Lewis Lung Carcinoma (LLC) cells.[23] Based on these principles, we constructed a genetically engineered and drug‐loaded P5091@RMPs‐R4F, which contains the RMP carrier, along with an SR‐B1‐targeting peptide, and a USP7 inhibitor. The gene discussed is USP7; the disease is lung carcinoma.