Furthermore, expression of inflammatory cytokines including Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α) were significantly decreased in livers of hADMSCs-Exo group compared with those of the LFG and REG, demonstrating effective anti-inflammatory effects of hADMSCs-Exo in liver fibrosis mice. This evidence concerns the gene TNF and Hepatic fibrosis.