MET and non-small cell lung carcinoma: In NSCLC patients harboring METex14 or METamp, additional MET activating mutations have been clinically documented and preclinically characterized to confer resistance to type I MET inhibitors (i.e., crizotinib, capmatinib and savolitinib) while being sensitive to type II MET inhibitors (i.e., cabozantinib, glesatinib and merestinib) [7–10].