Finally, we show that miR-132-3p overexpression as well as KLF7 downregulation ameliorates EndMT in an in vitro model of diabetes-associated EndMT, thereby identifying both miR-132-3p and KLF7 as novel regulators of aortic stiffening-associated EndMT in type 2 diabetes mellitus. Here, KLF7 is linked to type 2 diabetes mellitus.