Out of these four predicted targets, only KLF7 is significantly upregulated in aortas of diabetes patients whereas DNMT3a, ZBTB20 and PTEN remain unaltered when compared to control subjects (KLF7 2.2-fold, p < 0.01; DNMT3/ZBTB20/PTEN not significant, Fig. 2E). The gene discussed is DNMT3A; the disease is diabetes mellitus.