IGF1R and hepatocellular carcinoma: The results are illustrated in Fig. 5 A and 5B. When HCC cells were transfected with siRNA IGF-1R lentivirus, the expression levels of IGF-1R and p-IGF-1R decreased significantly, and the levels of p-Akt, p-mTOR, p-MEK and p-ERK also decreased, suggesting that the activation levels of PI3K/Akt and Ras/Raf/ERK signaling pathways were inhibited when IGF-1R expression was downregulated (**p < 0.01).