IGF1 and hepatocellular carcinoma: To investigate the effect of IGF-1R on HCC cell migration, SK-Hep1 and HepG2 cells were treated with single drug sorafenib: IGF-1 (100 ng/mL) + sorafenib (4 μM), IGF-1 (100 ng/mL) + sorafenib (4 μM) + PPP (100 nM) or IGF-1 (100 ng/mL) + sorafenib (4 μM) + siRNA2 (IGF-1R), and the cell scratch healing test and Transwell test were performed.