AKT1 and hepatocellular carcinoma: In addition, silencing IGF-1R combined with sorafenib synergistically enhanced the apoptosis of HCC cells through the caspase / PARP pathway, suggesting that IGF-1R is involved in the proliferation, migration, and anti-apoptosis of HCC cells through the PI3K / Akt and Ras / Raf / ERK signaling pathways and negatively regulating the inhibitory effect of sorafenib on HCC.