Besides, compared with the control group, the protein level of synaptotagmin 1 in HT22 also decreased in the infected group (t-test: t(4) = 4, P = 0.0161), suggesting that the number and function of HT22 reduced because of apoptosis induced by TgCtwh6 tachyzoites infection (Fig. 4E, F). Here, SYT1 is linked to infection.