Besides the already known factor CCL26 (Eotaxin-3) expressed by stromal and epithelial cells (Additional file 1: Fig. S3G, 3J and 3L) known to regulate the eosinophilic trafficking to the esophagus in patients with EoE and to discriminate between EoE and GERD [27], other markers were pointed out, such as CXCL14, PDGFRA, CXCL12, ACVRL1, POSTN, NOX4 and LTBP4 (Fig. 2E). The gene discussed is NOX4; the disease is gastroesophageal reflux disease.