Therefore, such a specific profile, including increased levels of CXCL14, PDGFRA, CXCL12, ACVRL1, POSTN, NOX4, and LTBP4 in EoE by comparison with the GERD and control samples, may guide the correctness of diagnosis and might help to design accurate diagnostic panels. Here, NOX4 is linked to gastroesophageal reflux disease.