HAMP and chronic kidney disease: The strong influence of iron reserves on hepcidin expression, shown in healthy individuals as well as in patients with CKD [11, 13, 18–20], demonstrates the importance of relating levels of HEP-25 to the size of iron reserves and also consider the hepcidin/ferritin ratio (H/F ratio), which reflects the adequacy of hepcidin expression in relation to iron stores [21].