LEPR and Hyperglycemia: To explore how obesity and diabetes influence serine, glycine and one-carbon (SGOC) metabolism, we quantified serine, glycine and methionine across tissues in an established mouse model of morbid obesity, insulin resistance and hyperglycaemia (leptin receptor-deficient db/db mice on a black Kaliss background (BKS-db/db)) and compared results with age-matched wild-type C57BL/6J controls.