We first studied the expression of SERPINE1 in the pan-cancer data set of TCGA, and the results showed that the expression levels of SERPINE1 in Colon adenocarcinoma (COAD), Colon adenocarcinoma/ Rectum adenocarcinoma Esophageal carcinoma (COADREAD), Stomach and Esophageal carcinoma (STES), Head and Neck squamous cell carcinoma (HNSC) and STAD were significantly increased (p < 0.001), In contrast, SERPINE1 expression in Liver hepatocellular carcinoma (LIHC), Kidney renal papillary cell carcinoma (KIRP), Kidney Chromophobe (KICH) significantly decreased (p < 0.001) (Fig. 4A). The gene discussed is SERPINE1; the disease is colon adenocarcinoma.