The results showed that the high expression of SERPINE1 had poor prognosis in Glioma (GBMLGG), Brain Lower Grade Glioma (LGG), Pan-kidney cohort (KIPAN), Uveal Melanoma (UVM), Mesothelioma (MESO), STES, HNSC, Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), LIHC, Lung squamous cell carcinoma (LUSC), Lung adenocarcinoma (LUAD) (p < 0.01) (Fig. 4B). This evidence concerns the gene SERPINE1 and central nervous system cancer.