Comparison of perturbed signaling pathways between blood and tissue data revealed that several subsignaling pathways involved in signal transduction (e.g., RHO GTPase cycle), neuronal system (e.g., N-methyl-D-aspartate receptor [NMDAR] signaling), cell cycle, transport of small molecules, metabolism, and so on, which have close links with the reported GBM-associated pathways mentioned above, are reflected in GBM blood (Fig. 3c). This evidence concerns the gene RHO and glioblastoma.