APP and Alzheimer disease: As a protein-sorting receptor, SorCS1 targets not only NRXs (Savas et al, 2015; Ribeiro et al, 2019) but also other molecules related to AD pathology and synaptic and neuronal functions such as APP itself (Lane et al, 2010; Reitz et al, 2011; Hermey et al, 2015), AMPA-type glutamate receptor (Savas et al, 2015) and the neurotrophin receptor TrkB (Subkhangulova et al, 2018).