Interestingly, some research identified certain genes found in the p53 signal pathway as the targets of miR‐1228‐5p,38, 39 which proves to be consistent with the background of NCI‐H1299 and NCI‐H23 cells line in our study (The source of NCI‐H1299 and NCI‐H23 was lung cancer patient with p53 deletion). This evidence concerns the gene TP53 and lung cancer.