For instance, Guo et al. in 2021 have reported that their microneedle-based wound dressing can reduce the IL-6 secretion by 1.8 times by day 9. Moreover, increased wound infection levels were associated with the increased secretion of IL-6 and TNF-α, whereas reduced infection levels led to the negligible expression of such pro-inflammatory factors, which is also evident from our results. The gene discussed is TNF; the disease is infection.