Although our high-resolution 4C analysis revealed extensive conformational structures of EBV genomes during EBV latency in marmoset B-cells and human GC, further studies are required to resolve some of these more complicated functions of CTCF and to better understand how EBV has exploited CTCF binding sites to coordinate gene regulation and genome propagation during latent infection. The gene discussed is CTCF; the disease is disease arising from reactivation of latent virus.