KRAS and cancer: Fig 2A provides an overview of the pathogenic DNA variants identified in these 50 patients. In 10 patients (20%), HGD was suspected after NGS analysis. All of which were classified as malignant tumors during histopathological analysis or follow-up. Two benign specimens showed LGD (KRAS mutation), both were classified as pancreatitis. Four out of six IPMNs showed LGD (Fig 2B and 2C).