In the GLP-1 RA arm, a total of 12,319 participants (mean age, 54.1 years; 54.4% women, mean baseline BMI, 33.9 kg/m2; mean baseline HbA1c level, 7.7%; mean follow-up duration, 38.1 weeks; mean duration of diabetes, 8.0 years) were included in the multivariate meta-analysis. The gene discussed is GLP1R; the disease is diabetes mellitus.