The Src-family tyrosine kinase, LYN, is a proto oncogene that interacts with proto oncogene inhibitory guanine nucleotide (G) binding protein alpha 2 (GNAI2) involved in the hormonal regulation of adenylate cyclase and G protein subunit gamma 10 required for GTPase activity and amplified in melanoma (GNG10) [26–29]. The gene discussed is LYN; the disease is melanoma.