A search of The Human Protein Atlas, identified 20 upregulated differentially expressed proteins associated with cancer (AK1, CLU, CKB, CNN1, DES, FNDC1, GNAI2, GNG10, LGALS, LYN, P3H4, PTK7, RPM3, S100A4, SYNM, SYNPO2, TAGLN, SERPIN1, SERPINB1, VWA1) and 6 that are specifically upregulated in non-hepatobiliary NENs (CKB, CLU, LGALS1, LYN, SERPINB1, TAGLN) [25,30–36]. This evidence concerns the gene DES and cancer.