A search of The Human Protein Atlas, identified 20 upregulated differentially expressed proteins associated with cancer (AK1, CLU, CKB, CNN1, DES, FNDC1, GNAI2, GNG10, LGALS, LYN, P3H4, PTK7, RPM3, S100A4, SYNM, SYNPO2, TAGLN, SERPIN1, SERPINB1, VWA1) and 6 that are specifically upregulated in non-hepatobiliary NENs (CKB, CLU, LGALS1, LYN, SERPINB1, TAGLN) [25,30–36]. The gene discussed is S100A4; the disease is cancer.