Meanwhile, curcumin was also reported to be effective in counteracting cerebral ischemia-induced oxidative stress and glutamate excitotoxicity (Subedi and Gaire 2021) and proved to be effective in inhibiting the expression of monoamine oxidase (MAO-A and MAO-B) enzymes leading to increased levels of norepinephrine, serotonin, and dopamine (Bhat et al. 2019; Matias et al. 2021). This evidence concerns the gene MAOA and brain ischemia.