Given previous findings demonstrating B cell infiltration in GFAP:GP, STOP:GP and MOG:GP conditions [57, 75], in conjunction with our observed disease manifestations (Fig. 1b), we questioned whether single-cell immune repertoire sequencing would provide insight into selection fingerprints of CNS B cells and their functional role in the context of CNS infection and autoimmunity. This evidence concerns the gene MOG and Autoimmunity.