LMNA and familial partial lipodystrophy: Furthermore, hypersensitivity to HS has been reported in dermal fibroblasts obtained from Hutchinson–Gilford progeria syndrome (HGPS) and familial partial lipodystrophy (FPLD) patients carrying G608G and R482Q/W mutations in the lamin A/C gene (LMNA), respectively (Paradisi et al., 2005; Vigouroux et al., 2001).