In conjunction with this work and based on the previous facts about the importance of phosphorus compounds as inhibitor for the Alzheimer’s disease, we have synthesised some novel triphenylphosphoranylidenesilol-ylidene aniline, triphenylphosphoranylidene-silolone, triphenylphosphoranylidenebutanoates, and cyclobutenes, as AChE inhibitors. This evidence concerns the gene ACHE and early-onset autosomal dominant Alzheimer disease.