The median sPD-1 and sPD-L1 content in the blood plasma of healthydonors was 29.25 (14.9–45.5) pg/ml and 36.23 (9.83–73.1) pg/ml,respectively; and in the group of GC patients – 12.57 (7.7–19.7)pg/ml and 21.83 (10.1–74.3) pg/ml. The gene discussed is HOXD13; the disease is gastric cancer.