FGF21 and metabolic dysfunction-associated steatotic liver disease: FGF-21 is predominantly secreted by the liver, with a broad continuum of tissuespecific autocrine-, paracrine-, and endocrine-mediated metabolic pathways.33 Of note, FGF-21 induces production and secretion of adiponectin through PPAR-γ in adipose tissue and is capable of inducing peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α).34 Circulating levels of FGF-21 and FGF-21 mRNA expression are increased in individuals with NAFLD.