Based upon developmental physiology, hypogonadism can be defined as an impaired gonadal function, based on the patient’s age, which may result in a decreased secretion of sex steroids, AMH and/or inhibins, and/or a disrupted gamete production.32 Hypogonadism has different clinical presentations and health consequences depending on the age at which it is established, the gonadal cell population initially impaired and the level of the HPG axis primarily affected (Table 1). This evidence concerns the gene AMH and hypogonadism.