Indeed, girls with complete gonadal dysgenesis due to Turner syndrome have normal FSH and LH levels between ages 4 and 10 years,33 and a similar pattern is observed in anorchid boys 34–36 and in boys with primary hypogonadism associated with cryptorchidism,37 indicating that approximately 35–75% of the patients would go undiagnosed if gonadotropin elevation was required to diagnose primary gonadal failure in patients of prepubertal age.38 The gene discussed is PLOD1; the disease is Hypergonadotropic hypogonadism.