HAVCR1 and acute kidney injury: While KIM-1 is rarely expressed in normal renal tissue, after the injury of renal proximal convoluted tubular epithelial cells, KIM-1 is involved in the process of early renal injury and repair or the fibrosis of renal interstitium.16 Domestic scholar Wang JJ et al 17 found that the level of KIM-1 in AKI patients increased significantly at three, six, and 12 hours after operation in a prospective multicenter study including 149 patients.