Fifteen ABO genotypes have been identified.6 Whereas a few studies have been carried out on the association of ABO blood groups with CAD, there are hardly any published reports from South Asia on the relationship between ABO genotypes and AMI, except one recent report from India.7 Therefore, the present study aimed to explore the relationship of blood groups and ABO genotypes with AMI in a Pakistani population in Karachi and determine any influence of well-known risk factors for CAD on the relationship of ABO genotypes with AMI in this population. The gene discussed is ABO; the disease is coronary artery disorder.