However, it has been hypothesized that ABH antigens affect the plasma clearance rates of VWF, which results in elevation of VWF levels in plasma and ultimately increases the risk for myocardial infarction.21 It has also been hypothesized that platelet aggregation is supported by the B antigen, hence leading to myocardial infarction. This evidence concerns the gene VWF and myocardial infarction.