Ułamek et al24 study confirmed that the potential mechanisms of tau protein in the brain after ischemia, including a series of pathophysiological reactions such as oxidative stress, apoptosis, autophagy, excitotoxicity, neuroinflammation, endothelium, angiogenesis and mitochondrial dysfunction, were involved in the progression of PSD. The gene discussed is MAPT; the disease is ischemia.