Idebenone is an effective antioxidant and CoQ10 analogue.26 It has been shown that the anti-inflammatory effect of NLRP3-mediated injury in I/R can be improved by inhibiting the activation of NLRP3, which may provide new insights into the treatment strategy of ischemic stroke.27 Reducing oxidative stress and improving brain inflammation can play a neuroprotective role and treat PSD.28 Here, NLRP3 is linked to ischemic stroke.