Hyponatremia in DM can also be due to hyporeninemic hyperaldosteronism associated increased ADH release or from insulin induced Aquaporin-2 channels potentiation.20 Hyponatremia in HTN can be from associated chronic kidney disease, thiazides, renin secreting tumors and renal artery stenosis associated renal ischemia.16 This evidence concerns the gene INS and chronic kidney disease.