AQP2 and hypertensive disorder: Hyponatremia in DM can also be due to hyporeninemic hyperaldosteronism associated increased ADH release or from insulin induced Aquaporin-2 channels potentiation.20 Hyponatremia in HTN can be from associated chronic kidney disease, thiazides, renin secreting tumors and renal artery stenosis associated renal ischemia.16