Some studies evaluated stromal CD10 immunoexpression and found no relation with tumor grade, stage, presence of lymph node or distant metastases, or survival.2 In a study that compared CD10 immunoexpression in the urothelial tissues and stroma, high tumorous CD10 was associated with tumor stage and grade, while stromal CD10 was associated with younger age.14 The contradiction regarding stromal immunoexpression is probably related to the different clones. This evidence concerns the gene MME and neoplasm.