VWF and congenital thrombotic thrombocytopenic purpura: TTP is characterized by the deposition of intravascular platelet microthrombi induced by autoantibody‐mediated deficiency of ADAMTS13, a von Willebrand factor (VWF)‐cleaving protease,8 resulting in thrombocytopenia, microangiopathic hemolytic anemia (MAHA), renal abnormalities, neurologic disturbances, and fever.